CoQ10 has not been approved by the Food and Drug Administration (FDA) for migraine prevention. However, the American Headache Society (AHS), the American Academy of Neurology (AAN), and the Canadian Headache Society feel confident enough in its safety and potential efficacy to offer specific recommendations for its use in prophylactic migraine therapy.
Uses
Coenzyme Q10 is a compound that is found in mitochondria—the tiny organelles that exist in nearly every cell from which food combines with oxygen to create energy. In fact, mitochondria are often referred to as “the powerhouses of cells.”
When these tiny structures don’t function properly, nearly every system in the body can be affected. Mitochondrial problems are linked to a variety of diseases and conditions.
Because these metabolic imbalances take place not only during migraine attacks but also may exist in between them, supplementation with CoQ10 may stabilize imbalances, potentially preventing migraines.
Effectiveness
Only a few studies have looked at coenzyme Q10 as a migraine prophylactic, but some studies suggest that they may be beneficial in preventing episodic migraines (occurring in fewer than 15 days per month).
In an early study published in the journal Neurology, 43 people with episodic migraines received either 100 milligrams (mg) of CoQ10 or a placebo three times a day for three months. At the end of the study, the participants who received CoQ10 self-reported around 50% fewer migraine attacks than those who took the placebo.
A 2019 review of studies reported similar findings. The review, published in Acta Neurologica Scandinavica, analyzed five studies involving a total of 346 participants (120 children and 226 adults).
According to the researchers, CoQ10 was able to reduce the number of attacks per month along with their duration. What it was not able to do is reduce the actual severity of the symptoms.
Side Effects
One thing that makes CoQ10 supplementation attractive to people with migraines is that it has few side effects, and those that have been documented have been mild.
The most commonly reported side effects of CoQ10 include:
Nausea Diarrhea Abdominal pain Heartburn Appetite loss Headache Dizziness Fatigue Insomnia and other sleep problems Irritability Sensitivity to light Skin rash Elevated liver enzymes
Dosage
As a nutritional supplement, coenzyme Q10 is sold as a pill, capsule, or gelcap to be taken by mouth. To ensure quality and purity, opt for brands that have been voluntarily tested and certified by an independent authority like the U.S. Pharmacopeia (USP), ConsumerLab, or NSF International.
Coenzyme Q10 can also be derived from food sources, including oily fish, organ meats, and whole grains. But it would be difficult to get the recommended therapeutic amounts from food sources alone.
Warnings and Interactions
There are few medications known to potentially interact with coenzyme Q10 supplements. They include:
Blood thinners: CoQ10 may make blood thinners such as Coumadin (warfarin) less effective. Insulin: CoQ10 may lower blood sugar. While potentially beneficial to people with diabetes, CoQ10 may lead to hypoglycemia (abnormally low blood sugar) in people on anti-diabetes drugs. Cancer treatments: The use of CoQ10 before or during chemotherapy or radiation may interfere with cancer treatment.
Advise your healthcare provider if you take these or any other medications before trying coenzyme Q10 to prevent migraine headaches.
Coenzyme Q10 has not been established as safe during pregnancy or breastfeeding. So if you are pregnant, planning to conceive, or are breastfeeding, it is best not to take this supplement just to be safe.
A Word From Verywell
If you have episodic migraine headaches, taking coenzyme Q10 supplements might be a natural and effective way to prevent them. Before taking any supplement, however, speak with your healthcare provider to ensure you can take them safely based on your individual health concerns.
Once you start taking this supplement, be patient. It may take several weeks before you notice any difference in the incidence or duration of migraine symptoms. Let your healthcare provider know if you experience any side effects, particularly fatigue, nausea, vomiting, jaundice, or any other signs of liver toxicity.
